… and testosterone signaling pathways in Sertoli cell proliferation… process, for example 5α-dihydrotestosterone
(DHT) regulates … cell cycle arrest by interacting with 17β-estradiol (E2) (106). …

… The cAMP/PKA signaling pathway participates in Sertoli cell differentiation, SSC self-renewal …
in immature rat SCs activates the caspase 9 mediated intrinsic apoptotic pathway [118]. …

… by estrogen (A) and androgen (B) after 17β-estradiol (E2) (10 −9 M… These apoptotic bodies
are phagocytosed by Sertoli cells. … In addition, estrogen also activates signaling pathways via …

… , Sod2, Cat, and Gpx1), apoptosis-related genes (Bcl2 and Bax), … regulated NR3C4 expression
in Sertoli cells and immature … Leydig cell maturation, other signaling pathways may be …

… to jointly regulate the proliferation and apoptosis of SSCs (13)… the testis by insulin and IGF-I
in rats (22). When PI3K-specific … Akt signaling pathway, MAPK signaling pathway, metabolism …

… stem cells receive regulatory signals not only from Sertoli cells … In the same study, 17β-estradiol
was also found to activate … disrupting signaling pathways and cellular communications. …

… by immature, not yet terminally differentiated Sertoli cells and … Sertoli cells, the apoptosis of
spermatocytes, spermatids and … converted into 17β-estradiol and 5α-dihydrotestosterone (DHT…

… Metabolism, as well as the key signaling pathway mediating metabolic activity in various …
also regulate Sertoli cell metabolism. 5α-Dihydrotestosterone and 17β-estradiol are reported to …

… regulate the process of proliferation of the Sertoli cells. The … 17α,20β‐dihydroxy‐4‐pregnen‐3‐one,
and 17β‐estradiol. 11‐… and 5α‐dihydrotestosterone are the major androgens found …

… -apoptotic Bcl-2 protein [9, 10] and an up-regulation of pro-… The physiological effects of IGF1
involve signaling pathways … in the Sertoli cells in the cross-section from the control group, …